WebJul 9, 2024 · The cardiac hypertrophy model based on transverse aortic ligation has been applied to study its cardioprotective effect, and the results revealed that scutellarin was capable of treating hypertension and myocardial hypertrophy by modulating the Ca 2+ -mediated calcineurin pathway ( Pan et al., 2010 ). WebRb1 also suppresses the expression of pro-hypertrophic microRNA-155 (miR-155) in LPS- or Ang II-stimulated macrophages. Furthermore, in activated macrophages, miR-155 is in part accountable for the suppressive effect of Rb1 on the production of IL-6, an inflammation mediator with pro-hypertrophic functions in the heart.
Myocyte hypertrophy and apoptosis: a balancing act
WebApr 9, 2024 · Another mechanism that contributes to muscle wasting is an inability to activate pro-hypertrophic pathways, which is a condition known as anabolic resistance. In this sense, the key mediator of myofibrillar protein synthesis and muscle growth is the mechanistic target of rapamycin complex 1 (mTORC1) pathway. WebPathological cardiac hypertrophy, which is a compensatory mechanism established to maintain cardiac function in response to neurohormonal or mechanical stresses, … magnavox mc345 universal remote
PHD Finger Protein 19 Promotes Cardiac Hypertrophy via Epigenetically …
WebMay 31, 2024 · Although the pro-hypertrophic role of GATA4 in cardiac hypertrophy has been well established, the negative regulation to counteract its hyperactivation during this … WebJun 1, 2016 · Among the numerous pro-hypertrophic factors, ROS has been highlighted for its crucial participation in various cardiovascular diseases (for example, hypertension, atherosclerosis and heart failure ... WebFeb 21, 2024 · Aims In contrast to the membrane bound adenylyl cyclases, the soluble adenylyl cyclase (sAC) is activated by bicarbonate and divalent ions including calcium. sAC is located in the cytosol, nuclei and mitochondria of several tissues including cardiac muscle. However, its role in cardiac pathology is poorly understood. Here we investigate … cpin dod