Drugs containing convallatoxin

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August undefined, 2024

WebHerbal medicines have been effectively used for the treatment of cardiovascular diseases for many years. ... (whole plant extracts) 80-900 mg per day; containing 1.5 mg Vitexin (Crataegus flavanoid) bid Lily of the Valley Root (Convallaria) 100-400 mg per day, containing Convallatoxin (Convallaria alkaloid) 0.4 mg bid WebSep 30, 2024 · Convallatoxin (CNT) is a natural cardiac glycoside with anti-inflammatory pharmacological properties. ... (Zhong Qiao Xin Zhou Biotechnology, China) were cultured in DMEM medium (12100–046, Gibco, USA) containing 10% FBS (SH30084.03, Hyclone, USA). The cells were plated, and exposed to ox-LDL (100 μg/mL; UnionBiol, China) …

Convallatoxin CAS:508-75-8 Isoprenoids High Purity - BioCrick

WebPlant Based Drugs and Medicines. By Leslie Taylor, ND. In 2001, there were at least 120 distinct chemical substances derived from plants that are considered as important drugs currently in use in one or more countries in the world. These chemical substances are shown in the table below. Several of the drugs sold today are simple synthetic ... WebNov 14, 2024 · Convallatoxin inhibits the proliferation of K562 cells, promotes mitochondria-related apoptosis, and induces cell cycle arrest in the S and G2/M phases, which are related to the downregulation of Akt … financial webpage tspc

Convallatoxin, a Dual Inducer of Autophagy and Apoptosis

WebThe plant Digitalis purpurea (foxglove) contains the cardioactive glycoside digoxin. In the lily family, squill ( Scilla maritima) contains scillaren, and lily of the valley ( Convallaria … WebNov 14, 2016 · We identified convallatoxin, a novel cell-targeting antiviral that inhibits CMV infection by decreasing the synthesis of viral proteins. At doses low enough for cells to tolerate, convallatoxin was able to inhibit primary isolates of CMV, including those resistant to the anti-CMV drug ganciclovir. WebMar 24, 2014 · Semi-synthetic analogs of vinblastine are currently used in combination with other chemotherapeutic drugs for the treatment of cancers such as leukemias, ... Herein, we found that convallatoxin (3-O-R-L-rhamnopyranosylstrophanthidin, CNT), a natural small molecule, induces cell death through a combination of apoptosis and autophagy. ... gs wri

Convallatoxin inhibits IL-1β production by suppressing …

Convallatoxin, the primary cardiac glycoside in lily of the …

WebConvallatoxin was obtained from Pfaltz & bauer (Waterbury, CT, USA). Peruvoside was purchased from Research Plus, Inc. (Barnegat, NJ, USA). Strophanthidin, Thiazolyl blue … WebFeb 7, 2024 · CON induced cytotoxic effects in A549 cells. a Chemical structure of convallatoxin.b Growth inhibition of A549 cells by CON expressed as number of cells after 24, 48, and 72 h of treatment obtained by the Trypan blue assay. The data shown represent the scatter plot (+bars representing the mean of three independent experiments) ***p < … gswrd aircraftWebNov 26, 2024 · Convallatoxin inhibits IL-1β production by suppressing zinc finger protein 91 (ZFP91)-mediated pro-IL-1β ubiquitination and caspase-8 inflammasome activity. Yue … financial web developers

"Webagainst cardiac dysfunction.Standardized convallaria drug powder contains 0.2 to 0.3% cardiac glycosides and is adjusted to a pharmacological activity equivalent to 0.2% … " - Drugs containing convallatoxin

Drugs containing convallatoxin

WebBackground: Aberrant activation of STAT3 is frequently encountered and promotes survival, cellular proliferation, migration, invasion and angiogenesis in tumor cell. Convallatoxin, … WebConvallatoxin is a cardiac glycoside isolated from Adonis amurensis Regel et Radde. Convallatoxin ameliorates colitic inflammation via activation of PPARγ and suppression of NF-κB. Convallatoxin is a P-glycoprotein (P-gp) substrate and recognized Val982 as an important amino acid involved in its transport.

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WebSep 26, 2014 · Drug rescue of P-gp processing mutants containing an arginine at each position in TM5 was used to identify positions facing the lipid or internal aqueous chamber. WebSep 1, 2012 · Lily of the Valley Root (Convallaria) 100-400 mg per day, containing Convallatoxin (Convallaria alkaloid) 0.4 mg bid …

WebConclusion and implications: We show for the first time that convallatoxin-mediated inhibition of ZFP91 is an important regulatory event that prevents inappropriate … WebJan 14, 2024 · Description. Convallatoxin is a cardiac glycoside isolated from Adonis amurensis Regel et Radde. Convallatoxin ameliorates colitic inflammation via activation of PPARγ and suppression of NF-κB. Convallatoxin is a P-glycoprotein (P-gp) substrate and recognized Val982 as an important amino acid involved in its transport.

WebMaterials and methods: Aliquots of a drug-free serum pool and a digoxin serum pool were supplemented with nanograms to 1 μg quantities of convallatoxin or 1.0 and 2.5 μL of lily of the valley extract per milliliter of serum followed by measurement of digoxin concentrations using the LOCI and ADVIA Centaur digoxin assays. WebConvallatoxin is used as a cardiotonic. The dried rhizome, known as Convallaria root, has also been used as a cardiotonic and diuretic. In veterinary science, it has been used as a diuretic and cardiac stimulant. Cardiac glycosides compounds are potent inhibitors of cellular Na + /K + -ATPase.

WebNov 26, 2024 · Convallatoxin inhibits IL-1β production by suppressing zinc finger protein 91 (ZFP91)-mediated pro-IL-1β ubiquitination and caspase-8 inflammasome activity. Yue Xing, Yue Xing. Key Laboratory of Natural Medicines of the Changbai Mountain, Ministry of Education, Molecular Medicine Research Center, College of Pharmacy, Yanbian …

WebM2 macrophage polarization has been reported to promote tissue repair and attenuate plaque formation upon the expression of anti-inflammatory factors. Convallatoxin (CNT) is a natural cardiac glycoside with anti-inflammatory pharmacological properties. However, whether CNT protects against atherosclerosis (AS) and underlying mechanisms is … financial website propagandaWebWe identified convallatoxin, a novel cell-targeting antiviral that inhibits CMV infection by decreasing the synthesis of viral proteins. At doses low … gsw right lower leg icd 10WebDrug Formulation: This drug may be formulated in ethanol. Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months). HS Tariff Code: 2934.99.03.00. Biological target: Convallatoxin ameliorates colitic inflammation via activation of PPARγ and suppression of NF-κB. In vitro activity: gsw right femurWebconvallatoxin: ( kon'val-ă-toks'in ), A toxic glycoside isolated from lily of the valley ( Convallaria majalis ); used as a radiotonic agent and for its digitalislike actions. gsw registrationWebJul 1, 2014 · Materials and Methods Aliquots of a drug‐free serum pool and a digoxin serum pool were supplemented with nanograms to 1 μg quantities of convallatoxin or 1.0 and 2.5 μL of lily of the valley ... g-swrd aircraftWebDepending on the reaction of the Convallatoxin after taken, if you are feeling dizziness, drowsiness or any weakness as a reaction on your body, Then consider Convallatoxin … financial web portalWebApr 12, 2004 · There are over 30 glycosides and convallatoxin is the most toxic with an LD50 of 0.08 mg/kg body weight ( Fenton, 2002 ). Convallatoxin produces cardiac … financial web page design